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Monitor Carefully (three)pentobarbital will lower the extent or outcome of diazepam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Powerful or reasonable CYP3A4 inducers may well raise amount of diazepam elimination; for that reason, efficacy of diazepam may be lowered.pentobarbital will decrease the exten